Parthenium integrifolium, commonly known as wild quinine, American feverfew, or Eastern feverfew, is a robust, clump-forming perennial wildflower that is native to eastern and central North America.

This tough plant is highly valued for its unique cauliflower-like white blooms, exceptionally long blooming season, and remarkable drought resistance. 

It grows 2-4' tall and 1-2'wide, and does best in full sun, although it can tolerate light afternoon shade.

It prefers moist to dry, well-drained loams, but easily toleres heavy clay, poor sandy or rocky soils.

The unique, nectar-rich disk florets of the flowers attract a massive variety of beneficial insects, including native sweat bees, mining bees, predatory wasps, syrphid flies, and beeltes.

The common name "wild quinine" stems from World War I, when the plant was utilized by the U.S. Army as a substitute for the bark of the South American Cinchona tree to extract a malaria treatment during shortages. Historically, Native Americans (such as the Catawba) also utilized the tannin-rich leaves in teas to reduce fevers and applied poultices of the plant to treat burns. 

Host plant for numerous Lepioptera species.