Large-flowered trillium is an herbaceous perennial wildflower in the trillium family ( Melanthiaceae ). It is native to a wide area of eastern North America in rich forests and mesic slopes. The species epithet is Latin for “large-flowered.”

Plant in part to full shade in humus-rich, well-drained soils.

The flowers are among the largest and showiest of the trilliums with flowers being 2 to 4 inches across and held above the large bracts that are glossy and green. The flowers' nectar attracts early-emerging native bees and honeybees. In areas where the plant is abundant, the large leaves provide cover for small mammals. Large-flowered trillium looks great in mass plantings in woodland settings. It spreads slowly by rhizomes.

Host plant for Black-patched Clepsis Moth and the American Angle Shades Moth